Epitalon

Longevity
Pineal Tetrapeptide
Telomerase • Circadian Signaling
10mg

$54.99

Availability: In stock

For research purposes only.
Emma Lindsay research guide in a white lab coat with a steel blue blouse

Emma Lindsay

RESEARCH GUIDE

I’ve pulled together the key product details, research context, and supporting information so you can quickly decide whether this item lines up with your research goals.

Overview

Epitalon, also known as Epithalon or AEDG, is a short research peptide most commonly associated with healthy aging, sleep-wake regulation, and cellular longevity research. In plain English, researchers are interested in Epitalon because it has been studied for how cells age over time, how biological rhythms are regulated, and how cells respond to oxidative stress. This has made it a notable compound in research involving telomeres, circadian biology, age-related cellular change, and broader longevity-focused pathways.

Scientifically, Epitalon is a synthetic tetrapeptide with the amino-acid sequence Ala-Glu-Asp-Gly (AEDG) and is commonly described as a pineal-derived bioregulatory peptide analogue. Research has explored its relationship with telomerase activity, telomere maintenance, gene-expression regulation, circadian signaling, oxidative-stress responses, and cellular aging models. Much of this evidence comes from preclinical, cellular, and older translational research, so Epitalon is best positioned as an investigational longevity-research peptide rather than as a proven anti-aging therapy.

The Science Behind Epitalon
Explore how Epitalon is studied through telomerase, telomere biology, and pineal signaling research.

Epitalon, also known as Epithalon or AEDG, is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly. It is studied as a pineal-derived research peptide associated with telomerase activity, telomere biology, cellular aging models, circadian regulation, and stress-response pathways. Much of the scientific interest around Epitalon comes from its relationship to epithalamin research and from in vitro and preclinical studies exploring how short regulatory peptides may influence gene expression, protein synthesis, and cellular repair processes.

In cellular research, Epitalon has been studied for effects on telomerase-related pathways and telomere maintenance. Recent cell-line research has reported telomere-length changes associated with telomerase upregulation or alternative lengthening of telomeres activity, while broader reviews describe Epitalon as a highly bioactive pineal tetrapeptide with research interest across aging biology, antioxidant response, reproductive aging, immune signaling, and circadian models.

Is Epitalon Right for Your Research Goals?
Discover how Epitalon fits into longevity research and what considerations may be important before selection.

Epitalon may be relevant for research goals focused on cellular aging, telomere biology, telomerase activity, pineal signaling, circadian rhythm models, oxidative-stress response, and longevity-pathway investigation. It is often discussed in the context of biological aging research because telomere shortening, DNA repair, mitochondrial stress, immune aging, and circadian disruption are all connected to broader aging-biology models. Epitalon can also be useful as a comparison point alongside mitochondrial and longevity-oriented compounds such as NAD+, MOTS-c, SS-31, and Thymalin.

Epitalon should still be approached with caution because the research base is not the same as an approved clinical medicine. Much of the published work comes from preclinical, cell-based, animal, and region-specific clinical literature, and independent large-scale human safety data remain limited. Research contexts involving active malignancy or cancer-biology models, abnormal cell-proliferation concerns, pregnancy or breastfeeding, immune dysregulation, endocrine disorders, or use in competitive-sport settings deserve careful review.

Dosage, Reconstitution & Storage
General research-context dosing, reconstitution, handling, and storage information to help maintain peptide integrity.

Epitalon does not have an approved clinical dosing label, so dosage language should be presented as research-context information rather than personal-use instruction. In researcher-reported and longevity-medicine discussions, Epitalon is commonly described in exploratory ranges around 5-10 mg per day for short research windows of about 10-20 days. Some lower-dose discussions also describe 0.5-1 mg per day approaches, while older epithalamin-related literature is not directly interchangeable with synthetic Epitalon because the compounds and preparations are not identical. These ranges should be understood as research-context references only. Protocol design depends on the study model, concentration, route, cellular-aging endpoint, circadian endpoint, and safety controls.

A lyophilized Epitalon vial can produce different concentrations depending on the reconstitution volume used. The final concentration depends on the amount of peptide in the vial, the volume of diluent added, and the measurement system used in the research model.

For storage and handling, Epitalon should follow standard peptide-integrity practices. Store unopened lyophilized vials refrigerated when possible and protected from direct light, heat, and repeated temperature changes. Once reconstituted, keep refrigerated and avoid unnecessary warming, freezing, or repeated agitation. If mixing is needed after adding diluent, gently swirl the vial rather than shaking it. Aggressive shaking can create foaming and may reduce peptide integrity over time.

-SILVERLEAF MULTI-BUY OFFER-

BUY 4.
GET 1 FREE.

Add any 5 eligible peptides to your cart. The lowest-priced item is automatically free.

No coupon code required.

Researched in Combination With Epitalon

NAD+ 500 mg research compound vial from SilverLeaf Bio
NAD+
500mg
$89.99
SilverLeaf Bio MOTS-C 10 mg research vial front view
MOTS-c
10mg
$64.99
SS-31 10 mg research peptide vial from SilverLeaf Bio
SS-31
10mg
$149.99
SilverLeaf Bio GHK-Cu 50 mg research vial front view
GHK-Cu
50mg
$59.99

Research Guides & Resources

How to Pay With Bitcoin in Canada

Follow a simple step-by-step guide to buying Bitcoin in Canada and completing your SilverLeaf Bio order securely.

Peptide Research Beginner’s Guide

Learn the basics of peptide research, including reconstitution, measurement, handling, record-keeping, and good research practices.

Questions About This Peptide?

Meet NOVA — Your AI Research Assistant

Get instant answers about peptide biology, research applications, storage requirements, research pairings, shipping details, and more.

Trained on SilverLeaf Bio product information, educational resources, and research content.

Third-Party Tested

Quality you can trust.

FREE Shipping

On all Orders over $300

Earn Rewards

Collect points on every purchase

Canadian Focused

Family Owned & Operated

Shopping Cart
Ask Nova Ask Nova