Epitalon, also known as Epithalon or AEDG, is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly. It is studied as a pineal-derived research peptide associated with telomerase activity, telomere biology, cellular aging models, circadian regulation, and stress-response pathways. Much of the scientific interest around Epitalon comes from its relationship to epithalamin research and from in vitro and preclinical studies exploring how short regulatory peptides may influence gene expression, protein synthesis, and cellular repair processes.
In cellular research, Epitalon has been studied for effects on telomerase-related pathways and telomere maintenance. Recent cell-line research has reported telomere-length changes associated with telomerase upregulation or alternative lengthening of telomeres activity, while broader reviews describe Epitalon as a highly bioactive pineal tetrapeptide with research interest across aging biology, antioxidant response, reproductive aging, immune signaling, and circadian models.




