IGF-1 LR3

Performance
Long-Acting IGF-1 Analog
IGF-1 Receptor • PI3K/Akt • MAPK
1mg

$89.99

Availability: In stock

For research purposes only.
Emma Lindsay research guide in a white lab coat with a steel blue blouse

Emma Lindsay

RESEARCH GUIDE

I’ve pulled together the key product details, research context, and supporting information so you can quickly decide whether this item lines up with your research goals.

Overview

IGF-1 LR3 is a long-acting research analogue of insulin-like growth factor-1 studied for muscle growth, tissue development, recovery, and broader growth-factor signaling. In plain English, it is designed to remain active longer than natural IGF-1 and is researched for how it influences cell growth, muscle tissue, nutrient use, and repair processes. This makes IGF-1 LR3 especially relevant to research involving body composition, skeletal muscle biology, and the growth hormone/IGF axis.

Scientifically, IGF-1 LR3 is a modified form of IGF-1 that retains activity at the IGF-1 receptor while incorporating structural changes intended to reduce binding to IGF-binding proteins and alter its biological availability compared with native IGF-1. Its research profile centers on IGF-1 receptor signaling, downstream PI3K/Akt and MAPK pathways, protein synthesis, cellular proliferation, and GH/IGF-axis biology. Because its pharmacology differs from endogenous IGF-1, it is commonly used as a research tool for studying prolonged growth-factor signaling and tissue-response pathways.

The Science Behind IGF-1 LR3
Explore how IGF-1 LR3 is studied through growth-factor signaling, IGF-1 receptor activity, and cellular-remodeling research pathways.

IGF-1 LR3, also known as Long R3 IGF-1, is a synthetic analog of insulin-like growth factor-1 studied for its interaction with IGF-1 receptor signaling. It differs from native IGF-1 through an arginine substitution at the third amino acid position and the addition of 13 amino acids at the N-terminus. These structural changes are studied because they reduce interaction with insulin-like growth factor binding proteins, which can increase the amount of free analog available for receptor-pathway research.

The scientific interest around IGF-1 LR3 is connected to the broader GH/IGF axis, a signaling system associated with cellular growth, survival, protein synthesis, tissue remodeling, skeletal-muscle biology, and metabolic regulation. IGF-1 receptor activation is commonly studied through downstream PI3K/Akt and MAPK pathway models.

Is IGF-1 LR3 Right for Your Research Goals?
Discover how IGF-1 LR3 fits into growth-factor research and what considerations may be important before selection.

IGF-1 LR3 may be relevant for research goals focused on IGF-1 receptor signaling, anabolic pathway models, skeletal-muscle biology, tissue-remodeling research, cell-survival signaling, glucose-handling models, and GH/IGF-axis comparisons. It is especially useful as a research topic when the goal is to compare native IGF-1 with longer-acting or lower-binding-protein-affinity analogs. This makes IGF-1 LR3 a strong fit for studies examining bioavailability, receptor signaling, and growth-factor pathway intensity.

IGF-1 LR3 also requires careful research-context consideration because IGF-1 signaling intersects with glucose regulation, cellular proliferation, and growth-factor biology. Research contexts involving active malignancy or tumor biology, abnormal tissue growth, diabetes or hypoglycemia risk, insulin or glucose-lowering combinations, acromegaly-like growth-axis concerns, organ enlargement models, pregnancy or breastfeeding, hypersensitivity history, or uncertain injectable-material quality deserve additional caution and professional review. IGF-1 and related analogs are also prohibited in sport under WADA growth-factor categories, so the product should remain positioned for controlled research contexts only.

Dosage, Reconstitution & Storage
General researcher-reported dosing context, reconstitution, handling, and storage information to help maintain peptide integrity.

IGF-1 LR3 does not have an approved clinical dosing label, and no large controlled human dosing standard exists for research-product use. Researcher-reported exploratory protocols commonly discuss approximate ranges of 20-50mcg per day, with some higher exploratory references discussing 50-100mcg per day across short research windows of about 4-6 weeks. These ranges should be understood as research-context references only. Protocol design depends on the study model, concentration, route, glucose-monitoring considerations, tissue target, growth-factor endpoint, and safety controls.

Because IGF-1 LR3 is a potent growth-factor analog, dose-context language should remain cautious. The research purpose matters: cellular-signaling models, tissue-remodeling models, GH/IGF-axis comparisons, and body-composition research may each require different concentration assumptions and monitoring endpoints. A 1mg lyophilized IGF-1 LR3 vial can produce very different concentrations depending on the volume of bacteriostatic water or other research-appropriate diluent used.

For handling and storage, IGF-1 LR3 should follow standard peptide-integrity practices. Store unopened lyophilized vials refrigerated when possible and protected from light, heat, moisture, and repeated temperature changes. Once reconstituted, keep refrigerated, avoid repeated warming and cooling, and protect from light. If mixing is needed after adding diluent, gently swirl the vial rather than shaking it. Aggressive shaking can create foaming and may reduce peptide integrity over time.

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